Always interesting how these stories just resurface over and over and over thru the decades. The SUN is good the SUN is bad, MEAT is good, MEAT is bad etc. Most of it crafted by "special interests" in DC and their alliances with the BIGs(Food, Pharma and Ag). One has to stay aware of the corrupt narratives. As for the SUN...where is the earth and LIFE without IT! Just don't BURN
Not really as if you consider what sunscreen is: those with darker skin Afro-Americans, Indian, SE Asia have a natural sunscreen and takes longer to absorb the process of Vitamin D from sunlight.
I never put sunscreen on my kids and I’m glad we spent lots of time outdoors. Fear coupled with unnecessary products and practices is harming our health and our children’s.
I'm hoping the research/book will also address basal cell cancer. I've had it twice on my nose needing MOHS surgery to remove. I wear sunscreen on my face daily. About 2 years ago, after my surgeries, I switched away from traditional sunscreen to beef tallow sunscreen with Zinc Oxide.
Try topical fenbendazole cream 10% for basal cell lesions. Available on Amazon. Many, including myself, have had great success with it. There are some case reports here https://fenbendazole.substack.com
Dee Smith: I don't slather toxic sunscreen on, I use Zinc Oxide, unless you are insinuating that is toxic.
Basal cell tumors are avoided by using sunscreen, wearing protective clothing & hats or staying out of the sun. But as far as easily remedied, I wouldn't call having a hunk of skin removed surgically easy. I could show a graphic photo of the hole in my nose before it was stitched up, but I don't think anyone really wants to see that!
A friend of mine had one on his nostril. That nostalgia was removed & they used part of his ear to rebuild his nose. That's not mild either. What experience have you had with this?
I agree with everything you just said! I am a fair skinned women.. red hair.. never used sun screen.. I’m 78 ! Now I use ivermectin or fenbendazole on any “skin cancers” .. the healing has been seen and documented by my aesthetician.. 15 years now.. same professional.. I have only seen a dermatologist once in my life.. and tge first thing he said to me was.. oh. I see you are a sun worshipper.. I have always honored my time in the sun .. safely .. . What a pompous jerk! I never went back! That was 30 year ago.. I let him remove a basil call and a squamous cell carcinoma.. shoulder area.. but now .. I do it naturally. My vitamin. D levels are 80..
Early morning sun is the best and least harmful. Before 10 or 11am. No sunscreen needed then. Cover up in the hot afternoon sun. Or stay inside or in the shade. Early morning sun produces the most vitamin D without the harms. All the best!😊
I like the idea of this book (though it seems as if a long article might have done the trick, maybe the lengh of Robin Whittle's comment) because it "scientizes" a point of balance, which, as the poet Henry Reed said, "we have not got." Thirty years ago I watched a mother smear sunscreen thickly all over her red-headed kid, who was perfectly white and freckle-less, unlike the redheads with whom I'd grown up; I had something of the feeling Herman Melville described about Moby Dick - the creepiness of so much whiteness (not a racial comment!) and it occurred to me, the mother of a couple of little boys playing tennis with only their clothes covering their skin, that the chemicals in the sunscreen couldn't be doing that redhead much good. Balance! If your ancestors are from northern latitudes and your skin is either pale white or bright red, cover it with clothing and stay out of the sun when it's overhead (because if your great-great-grandma lived her life in Ireland, she NEVER experienced the sun overhead) but don't hunker down in a cave; your ancestors were out plowing fields and digging potatoes in the sun, after all. If, like me, you're the fortunate inheritor of Mediterranean genes, a little bit of summer sun won't kill you (it'll wrinkle you, though) and who knows whether the risk of skin cancer is greater than of debilitating depression?
I am a very old sun addict who has spent as much time as possible in the sun, without sun screens. Regardless of temperatures from 0 to 100-plus degrees Fahrenheit. My face is somewhat more wrinkled but not as much as most pasty make-up faces. It looks very healthy.
Since about the time chemtrails appeared in the mid to late nineties, I have been wondering about the effects of their chemicals on health. It is now obvious that the radiation arriving on Earth is not natural anymore after passing through an ocean of many different poisons, and much more. Like Morgellons fibers.
You are not wrong, you are aware. Chem bombing is mostly heavy metals, they are not chemicals. Chemicals are sprayed on crops, or used as herbicides. Best you can do for chemicals is avoidance. It is possible to chelate heavy metals, that is a complex topic.
You are correct. Arsenic from Lundburg organic rice was contaminated as the heavy metal was in the soil from conventional farming practices. Pest and herbicides commonly had arsenic as ingredients.
Large acerage was reclaimed by Lundburg after rigorous organic certification completion THAT DOES NOT TEST FOR HEAVY METALS.
The good news is that As and other heavy metals can be chelated and excreted.
You need a health practitioner, very unlikely to be an MD, who is competent
To remove a lot of arsenic from rice keep it in a jar filled with water and a spoon of Redmond Clay for some eight ours. During that time, shake it a few times. Rinse rice with clean water.
(1 of 2) The immune system needs at least 50 ng/mL circulating 25-hydroxyvitamin D, as measured in "vitamin D" blood tests, to function properly. This is 1 part in 20,000,000 by mass, also known as 125 nanomols per litre.
Many types of immune cell need this to supply their 25-hydroxyvitamin D to calcitriol (1,25-dihydroxyvitamin D) intracrine and paracrine signaling systems. These operate within an individual cell (intracrine) and to nearby cells, usualy of different types (paracrine). When a cell-type-specific condition is detected, the individual cell hydroxylates 25-hydroxyvitamin D to calcitriol and produced "vitamin D receptor" molecules (really the calcitriol receptor) which bind to the calcitriol inside the cell. The bound complex, in intracrine signaling, alters the cell's behavior, in a cell-type specific manner, by altering the transcription of dozens to hundreds of genes to mRNA molecules, which alters the cell's protein synthesis and so its behavior. Paracrine signaling is similar except that the intracellularly generated calcitriol diffuses out of the cell and reaches nearby cells, where its presence, at a concentration higher than the very low background level of hormonal calcitriol, changes their behaviour, again in a cell-type specific manner.
These intracrine and paracrine signaling systems are crucial to the ability of cells of many types, especially many types of immune cell, to respond to their changing circumstances. They are not related to, and are not affected by, the well-known hormonal (endocrine) signaling use of calcitriol: the kidneys hydroxylating 25-hydroxyvitamin D to maintain a very low level (concentration) of calcitriol in the bloodstream - 0.05 to 0.1 ng/mL, which the kidneys use to alter the behavior of several types of cell, in distant parts of the body, which are involved in calcium-phosphate-bone metabolism. This is the sole hormonal function of calcitriol. A hormone is a long-distance blood borne signaling molecule.
Neither vitamin D3 cholecalciferol nor 25-hydroxyvitamin D calcifediol (AKA "calcidiol") act as hormones. They are not signaling molecules.
Unfortunately most vitamin D researchers and vitamin D aware clinicians do not understand these intracrine and paracrine signaling systems. They may have heard of intracrine (or, incorrectly, autocrine) and paracrine conversion of 25-hydroxyvitamin D to calcitriol in various cell types, but this is normally only mentioned in passing, which can give the impression that this locally produced calcitriol just adds to the (very low, and stable) level of calcitriol in that part of the body. This is not the case, these are *signaling* systems, within and between cells.
They were only discovered in the last two decades and there are not yet, as far as I am aware, any tutorial explanations of them in the peer-reviewed literature.
I wrote a (non-peer-reviewed) tutorial in late 2020: https://en.wikipedia.org/wiki/List_of_Intel_Xeon_processors. Initially this was for autocrine and paracrine signaling, but I later realised that autocrine signaling is not the correct term here. In autocrine signaling, the intracellularly produced ligand, in this case calcitriol, leaves the cell and binds to receptors on the outside of the same cell's plasma membrane. "Intracrine" is the correct term, since the ligand binds to receptors in the cell's cytoplasm.
This comment is a mini-tutorial on 25-hydroxyvitamin D to calcitriol intracrine and paracrine signalling. A second, proper, tutorial is in this section https://vitamindstopscovid.info/00-evi/#02-compounds of my long page which cites and discusses many important research articles.
At https://vitamindstopscovid.info/00-evi/#02-compounds you can read of the research from Massachusetts General Hospital which shows, clearly, that the immune system needs at least 50 ng/mL circulating 25-hydroxyvitamin D to work properly, at least in respect of suppressing the bacterial pathogens which cause most post-operative infections.
At https://vitamindstopscovid.info/00-evi/#02-compounds you can read the recommendations of Prof. Sunil Wimalawansa - as he has written in several peer-reviewed articles and provided in an FLCCC/IMA webinar - on how much vitamin D3 to supplement, on average, per day, in order to maintain at least the 50 ng/mL level of circulating 25-hydroxyvitamin D the immune system needs, without the need for blood tests or medical monitoring. For 70 kg (154 lb) body weight, without obesity, 125 micrograms (5000 IU) is a good amount. The actual amount depends on body weight and obesity status, since by two mechanisms at least (https://vitamindstopscovid.info/00-evi/#obesity-deficit), obesity reduces the body's ability to maintain a good level of circulating 25-hydroxyvitamin D.
The rest of the page concerns how low circulating 25-hydroxyvitamin D greatly raises the risk of numerous conditions, including COVID-19, influenza, pre-term birth, preeclampsia, mental retardation in the child (all due to low maternal 25-hydroxyvitamin D in pregnancy https://vitamindstopscovid.info/00-evi/#3.2), dementia, neurodegeneration (https://vitamindstopscovid.info/00-evi/#3.3) and many chronic inflammatory disorders.
I am an electronic technician and computer programmer. Please don't take my word for any of this. I write these comments, and the web pages, to help people find and read the most pertinent research.
No question about sunlight, though this is hardly news. Some figured this out many decades ago and were not early. Dermatologists are sun avoidance idiots. Some of us choose to live where sun exposure is a daily reality. Skin cancer? If ones diet and lifestyle contains toxins look no further.
Thank you for this positive focus today. I'd appreciate less on anti- vax/Democrats, pro Republican white Christian nationalist agenda. How about reaching out beyond the MAGA/MAHA audience to include those of us who love the positive focus on human good food, local sustainable farming, and corporate takeover of our health system? All of which are non-partisan positions that might take you beyond the support of the Republican agenda.
(2 of 2) Many people think that they will generate the vitamin D3 they need to be healthy just by getting some sun exposure. However, they do not realise that the proper target is enough vitamin D3 to maintain 50 ng/mL circulating 25-hydroxyvitamin D all year round. (Ingested or UV-B -> skin produced vitamin D3 is hydroxylated, at the 25th carbon, primarily in the liver, so about 1/4 of it goes into circulation as 25-hydroxyvitamin D.) Many doctors think that 20 ng/mL, or perhaps 30 ng/mL, is sufficient for good health. However, they do not know that the immune system needs 50 ng/mL to work properly.
Another pair of related problems is that many people refer to all three compounds as "vitamin D". These are three separate compounds with very different roles in the body. They should aways be referred to specifically. This conflating of the three compounds as "vitamin D", and the well known hormonal role of calcitriol leads to the mistaken belief that "vitamin D is a hormone".
The lack of understanding of 25-hydroxyvitamin D to calcitriol intracrine and paracrine signaling leads many people to assume that the immune system works better with a higher level of circulating calcitriol. This is not the case - and it wouldn't make sense, since the kidneys set this level to whatever is necessary to maintain circulating calcium ions with a very narrow range of levels, just below saturation.
A related mistake is to state that "vitamin D regulates the immune system", or "vitamin D is an immunomodulator". This combines the conflation mistake with the lack of understanding of the intracrine and paracrine signaling systems. The immune system regulates itself, by the behaviors and inter-cell signaling systems (cytokines and the above-mentioned paracrine signaling) of the individual cells - but these can only work properly if many types of immune cell are supplied with enough 25-hydroxyvitamin D.
Stating that "vitamin D is a hormone" while suggesting that people supplement thousands of IUs of it every day raises alarm in many people since this sounds like mega-dosing on hormones. However, this is not what is happening.
There is very little vitamin D3, or the less effective vitamin D2, in foods, including vitamin D2/3 fortified foods. In the absence of substantial ultraviolet B exposure of ideally white skin, all year round, and in the absence of supplemental vitamin D3 (or D2 . . .), such foods would make a small but crucial contribution to the very low level of circulating 25-hydroxyvitamin D, such as keeping it above 15 ng/mL or so (very approximately). This would greatly reduce the risk of rickets, but vitamin D fortified food, or the natural sources (some oily fish) can only supply a fraction of the vitamin D3 we need to be healthy - to attain at least 50 ng/mL circulating 25-hydroxyvitamin D.
If there was no supplemental vitamin D3, we would be reliant on getting a very small amount of it via foods and then using ultraviolet B light on the skin to make the rest.
Ultraviolet light ca. 293 nanometre wavelength gives electrons sufficient energy to break a carbon-carbon bond in one of the linked carbon rings in 7-dehydrocholesterol, which naturally occurs in the skin, since it is the last step before cholesterol in one of the two pathways by which the body synthesises the cholesterol it needs. This broken bond enables the molecule to change shape and become vitamin D3 cholecalciferol.
This is the natural way our ancestors made most of their vitamin D3. The trouble is that the exact same wavelengths which do this also break bonds in DNA and so kill cells and predispose some cells which survive to become cancerous, perhaps years later.
There is no way of generating vitamin D3 in our skin, by the action of UV-B light, without this DNA and cellular damage and so raising the risk of cancer.
If there was no supplemental vitamin D3, we could optimise our health, including lowering the general risk of cancer, by some level of UV-B skin exposure (those with brown or black skin need more, or a lot more) which would get us some of the way to 50 ng/mL circulating 25-hydroxyvitamin D, while limiting the damage caused by the UV-B. We would also wear strong eye protection, since UV-B is very damaging to the eyes.
Fortunately, vitamin D3 supplementation is inexpensive and readily available. It is fine to take a larger amount every 7 to 10 days, such as a 1.25 milligram (50,000 IU) capsule every 10 days. It takes a few months to raise the level of circulating 25-hydroxyvitamin D, so it is not necessary to supplement vitamin D3 every day.
"5000 International Units" sounds like a lot, but it is 1/8000th of a gram a day - a gram every 22 years. I am not sure what the wholesale cost of this is now, but ca. 2020, pharma grade vitamin D3 was selling, from the handful of plants worldwide which make it by UV-B irradiating 7-dehydrocholesterol made from wool fat, for USD$2.50 a gram.
The book covers these issues and much, much more in an easy to understand and entertaining manner. Every person should find useful information about sunlight, vitD and their specific health concerns succinctly presented in the book. Bill Supple aka Ben Fen from Cancer is a Parasite.
No need to write a novel or even to cite ng/ml that lay people do not comprehend.
A dog doth chase its tail. If one lives in a temperate clime, supplementation is super easy and cheap. More and more about less and less is most definitely not the way forward.
You can get the same amount of vitamin D from 1 cent of a supplement as from lying down for 1 hour in the sun with minimal clothing if you're < 50 years old.
Always interesting how these stories just resurface over and over and over thru the decades. The SUN is good the SUN is bad, MEAT is good, MEAT is bad etc. Most of it crafted by "special interests" in DC and their alliances with the BIGs(Food, Pharma and Ag). One has to stay aware of the corrupt narratives. As for the SUN...where is the earth and LIFE without IT! Just don't BURN
I think it's important to study how human populations continued throughout the ages. Sunscreen is a new phenomenon.
Not really as if you consider what sunscreen is: those with darker skin Afro-Americans, Indian, SE Asia have a natural sunscreen and takes longer to absorb the process of Vitamin D from sunlight.
Dietary "choices" has to do with making the best possible decision.
Killing animals has consequences both physically and spirtually.
Knowledge about health is crucial.
I concur on CHOICES we as individuals make and knowledge is indeed crucial!
I never put sunscreen on my kids and I’m glad we spent lots of time outdoors. Fear coupled with unnecessary products and practices is harming our health and our children’s.
I'm hoping the research/book will also address basal cell cancer. I've had it twice on my nose needing MOHS surgery to remove. I wear sunscreen on my face daily. About 2 years ago, after my surgeries, I switched away from traditional sunscreen to beef tallow sunscreen with Zinc Oxide.
Try topical fenbendazole cream 10% for basal cell lesions. Available on Amazon. Many, including myself, have had great success with it. There are some case reports here https://fenbendazole.substack.com
You are shopping in the wrong mall. Basal cell is easily remedied and avoided.
Slathering your skin with toxic suncreen is the worst decision.
Dee Smith: I don't slather toxic sunscreen on, I use Zinc Oxide, unless you are insinuating that is toxic.
Basal cell tumors are avoided by using sunscreen, wearing protective clothing & hats or staying out of the sun. But as far as easily remedied, I wouldn't call having a hunk of skin removed surgically easy. I could show a graphic photo of the hole in my nose before it was stitched up, but I don't think anyone really wants to see that!
A friend of mine had one on his nostril. That nostalgia was removed & they used part of his ear to rebuild his nose. That's not mild either. What experience have you had with this?
Mary,
Having a "hunk" of skin removed simply means YOU did not know other
simple remedy and shopped at the wrong location. Moe's is a guarantee for scarring, that is permanent.
If the sun causes basal cell then why would your friend "get" one where the sun
don't shine? Clearly you have been mislead.
Basal cells are easily remedied though location dependent. Even squamous, a worse scenario, have simple remedy, again location dependent.
Toxins are the cause of all malignancy, Reread as often as necessary.
Thinking the sun your enemy is the greatest lie ever told.
Dermatology is a racket, a costly racket.
Educate thyself and do not repeat non science in a public forum.
I agree with everything you just said! I am a fair skinned women.. red hair.. never used sun screen.. I’m 78 ! Now I use ivermectin or fenbendazole on any “skin cancers” .. the healing has been seen and documented by my aesthetician.. 15 years now.. same professional.. I have only seen a dermatologist once in my life.. and tge first thing he said to me was.. oh. I see you are a sun worshipper.. I have always honored my time in the sun .. safely .. . What a pompous jerk! I never went back! That was 30 year ago.. I let him remove a basil call and a squamous cell carcinoma.. shoulder area.. but now .. I do it naturally. My vitamin. D levels are 80..
Early morning sun is the best and least harmful. Before 10 or 11am. No sunscreen needed then. Cover up in the hot afternoon sun. Or stay inside or in the shade. Early morning sun produces the most vitamin D without the harms. All the best!😊
Thanks for sharing this important info! It goes to show that we must NEVER stop questioning “the science.”
I like the idea of this book (though it seems as if a long article might have done the trick, maybe the lengh of Robin Whittle's comment) because it "scientizes" a point of balance, which, as the poet Henry Reed said, "we have not got." Thirty years ago I watched a mother smear sunscreen thickly all over her red-headed kid, who was perfectly white and freckle-less, unlike the redheads with whom I'd grown up; I had something of the feeling Herman Melville described about Moby Dick - the creepiness of so much whiteness (not a racial comment!) and it occurred to me, the mother of a couple of little boys playing tennis with only their clothes covering their skin, that the chemicals in the sunscreen couldn't be doing that redhead much good. Balance! If your ancestors are from northern latitudes and your skin is either pale white or bright red, cover it with clothing and stay out of the sun when it's overhead (because if your great-great-grandma lived her life in Ireland, she NEVER experienced the sun overhead) but don't hunker down in a cave; your ancestors were out plowing fields and digging potatoes in the sun, after all. If, like me, you're the fortunate inheritor of Mediterranean genes, a little bit of summer sun won't kill you (it'll wrinkle you, though) and who knows whether the risk of skin cancer is greater than of debilitating depression?
I am a very old sun addict who has spent as much time as possible in the sun, without sun screens. Regardless of temperatures from 0 to 100-plus degrees Fahrenheit. My face is somewhat more wrinkled but not as much as most pasty make-up faces. It looks very healthy.
Since about the time chemtrails appeared in the mid to late nineties, I have been wondering about the effects of their chemicals on health. It is now obvious that the radiation arriving on Earth is not natural anymore after passing through an ocean of many different poisons, and much more. Like Morgellons fibers.
Do you agree or can you explain why I am wrong.
You are not wrong, you are aware. Chem bombing is mostly heavy metals, they are not chemicals. Chemicals are sprayed on crops, or used as herbicides. Best you can do for chemicals is avoidance. It is possible to chelate heavy metals, that is a complex topic.
Even eating chickens and rice bombed me with heavy metal, arsenic.
You are correct. Arsenic from Lundburg organic rice was contaminated as the heavy metal was in the soil from conventional farming practices. Pest and herbicides commonly had arsenic as ingredients.
Large acerage was reclaimed by Lundburg after rigorous organic certification completion THAT DOES NOT TEST FOR HEAVY METALS.
The good news is that As and other heavy metals can be chelated and excreted.
You need a health practitioner, very unlikely to be an MD, who is competent
in detoxing from heavy metals...
To remove a lot of arsenic from rice keep it in a jar filled with water and a spoon of Redmond Clay for some eight ours. During that time, shake it a few times. Rinse rice with clean water.
Don't listen to the person who has the answers; listen to the person who has the questions. ~Albert Einstein
Information is not knowledge. The only source of knowledge is experience. You need experience to gain wisdom. ~Albert Einstein
Sharing some of my massive life long experiences in a nutshell:
Baby Boy Resurrected
I and the public know what all school children learn,
those to whom evil is done do evil in return.
In his poem, September 1, 1939, published just before votre Ami’s birth,
did Auden dismiss terrified-toddlers might become blessed with mirth?
His Pa and Ma made the deadliest of all possible sins, ensuring Ami to fail.
Even so, he would grow tall and strong, and no one ever landed in jail.
His uncles secluded Ami in mud, manure, mice, over triggered-dynamite.
What guided his trauma-locked consciousness during decades of fright?
Near-deaths, bombings, floggings, homelessness, hunger, hard slavery
solidified Ami’s life-long patience, honesty, bravery, and empathy.
His imagination soared out of untold numbers of books while he suffered.
Did Earth-connection, walk-abouts keep Ami from feeling too battered?
The shell of to whom evil is done slowly cracked from unbearable pains.
Sprouting spirituality and intuition that propelled miraculous gains.
Discernment and Universal Connections enhanced Ami’s Blessedness.
What gave him the strength to conquer Lonely Learned Helplessness?
Divine guidance led Ami’s transition from shyness to slowly grow bolder.
Wonderment surmounted onslaughts on his wellness while getting older.
Doctors diagnosed It’s all in your head until he could no longer cry.
They dug into books and could not find his What’s, How’s, Why’s?
An unknown Angel phoned Ami to say: Chemicals are making you sick!
He quickly grasped the seriousness of the global science pandemic.
His longing for true health pushed him to grow only the purest nutrition.
Did earth’s bounty add decades before his undertaking with a mortician?
Ami’s compassion desires to share reality lessons with a forgiving spirit.
Once with an ailing preacher who became too nervous to hear it,
the secret of avoiding the Human Collapse Disease-Disorder death.
Why did life-saving tips cause: You scare me! and not under his breath?
Do you know that belief entrapments cause people to suffer?
Do you want to learn lessons that Ami can offer?
Could you endure his Hells, without bitterness, going insane or die?
What else experienced I?
(1 of 2) The immune system needs at least 50 ng/mL circulating 25-hydroxyvitamin D, as measured in "vitamin D" blood tests, to function properly. This is 1 part in 20,000,000 by mass, also known as 125 nanomols per litre.
Many types of immune cell need this to supply their 25-hydroxyvitamin D to calcitriol (1,25-dihydroxyvitamin D) intracrine and paracrine signaling systems. These operate within an individual cell (intracrine) and to nearby cells, usualy of different types (paracrine). When a cell-type-specific condition is detected, the individual cell hydroxylates 25-hydroxyvitamin D to calcitriol and produced "vitamin D receptor" molecules (really the calcitriol receptor) which bind to the calcitriol inside the cell. The bound complex, in intracrine signaling, alters the cell's behavior, in a cell-type specific manner, by altering the transcription of dozens to hundreds of genes to mRNA molecules, which alters the cell's protein synthesis and so its behavior. Paracrine signaling is similar except that the intracellularly generated calcitriol diffuses out of the cell and reaches nearby cells, where its presence, at a concentration higher than the very low background level of hormonal calcitriol, changes their behaviour, again in a cell-type specific manner.
These intracrine and paracrine signaling systems are crucial to the ability of cells of many types, especially many types of immune cell, to respond to their changing circumstances. They are not related to, and are not affected by, the well-known hormonal (endocrine) signaling use of calcitriol: the kidneys hydroxylating 25-hydroxyvitamin D to maintain a very low level (concentration) of calcitriol in the bloodstream - 0.05 to 0.1 ng/mL, which the kidneys use to alter the behavior of several types of cell, in distant parts of the body, which are involved in calcium-phosphate-bone metabolism. This is the sole hormonal function of calcitriol. A hormone is a long-distance blood borne signaling molecule.
Neither vitamin D3 cholecalciferol nor 25-hydroxyvitamin D calcifediol (AKA "calcidiol") act as hormones. They are not signaling molecules.
Unfortunately most vitamin D researchers and vitamin D aware clinicians do not understand these intracrine and paracrine signaling systems. They may have heard of intracrine (or, incorrectly, autocrine) and paracrine conversion of 25-hydroxyvitamin D to calcitriol in various cell types, but this is normally only mentioned in passing, which can give the impression that this locally produced calcitriol just adds to the (very low, and stable) level of calcitriol in that part of the body. This is not the case, these are *signaling* systems, within and between cells.
They were only discovered in the last two decades and there are not yet, as far as I am aware, any tutorial explanations of them in the peer-reviewed literature.
I wrote a (non-peer-reviewed) tutorial in late 2020: https://en.wikipedia.org/wiki/List_of_Intel_Xeon_processors. Initially this was for autocrine and paracrine signaling, but I later realised that autocrine signaling is not the correct term here. In autocrine signaling, the intracellularly produced ligand, in this case calcitriol, leaves the cell and binds to receptors on the outside of the same cell's plasma membrane. "Intracrine" is the correct term, since the ligand binds to receptors in the cell's cytoplasm.
This comment is a mini-tutorial on 25-hydroxyvitamin D to calcitriol intracrine and paracrine signalling. A second, proper, tutorial is in this section https://vitamindstopscovid.info/00-evi/#02-compounds of my long page which cites and discusses many important research articles.
At https://vitamindstopscovid.info/00-evi/#02-compounds you can read of the research from Massachusetts General Hospital which shows, clearly, that the immune system needs at least 50 ng/mL circulating 25-hydroxyvitamin D to work properly, at least in respect of suppressing the bacterial pathogens which cause most post-operative infections.
At https://vitamindstopscovid.info/00-evi/#02-compounds you can read the recommendations of Prof. Sunil Wimalawansa - as he has written in several peer-reviewed articles and provided in an FLCCC/IMA webinar - on how much vitamin D3 to supplement, on average, per day, in order to maintain at least the 50 ng/mL level of circulating 25-hydroxyvitamin D the immune system needs, without the need for blood tests or medical monitoring. For 70 kg (154 lb) body weight, without obesity, 125 micrograms (5000 IU) is a good amount. The actual amount depends on body weight and obesity status, since by two mechanisms at least (https://vitamindstopscovid.info/00-evi/#obesity-deficit), obesity reduces the body's ability to maintain a good level of circulating 25-hydroxyvitamin D.
The rest of the page concerns how low circulating 25-hydroxyvitamin D greatly raises the risk of numerous conditions, including COVID-19, influenza, pre-term birth, preeclampsia, mental retardation in the child (all due to low maternal 25-hydroxyvitamin D in pregnancy https://vitamindstopscovid.info/00-evi/#3.2), dementia, neurodegeneration (https://vitamindstopscovid.info/00-evi/#3.3) and many chronic inflammatory disorders.
I am an electronic technician and computer programmer. Please don't take my word for any of this. I write these comments, and the web pages, to help people find and read the most pertinent research.
No question about sunlight, though this is hardly news. Some figured this out many decades ago and were not early. Dermatologists are sun avoidance idiots. Some of us choose to live where sun exposure is a daily reality. Skin cancer? If ones diet and lifestyle contains toxins look no further.
Thank you for this positive focus today. I'd appreciate less on anti- vax/Democrats, pro Republican white Christian nationalist agenda. How about reaching out beyond the MAGA/MAHA audience to include those of us who love the positive focus on human good food, local sustainable farming, and corporate takeover of our health system? All of which are non-partisan positions that might take you beyond the support of the Republican agenda.
It's just a maga operation, flavored a bit differently to appeal to some “alt” types.
(2 of 2) Many people think that they will generate the vitamin D3 they need to be healthy just by getting some sun exposure. However, they do not realise that the proper target is enough vitamin D3 to maintain 50 ng/mL circulating 25-hydroxyvitamin D all year round. (Ingested or UV-B -> skin produced vitamin D3 is hydroxylated, at the 25th carbon, primarily in the liver, so about 1/4 of it goes into circulation as 25-hydroxyvitamin D.) Many doctors think that 20 ng/mL, or perhaps 30 ng/mL, is sufficient for good health. However, they do not know that the immune system needs 50 ng/mL to work properly.
Another pair of related problems is that many people refer to all three compounds as "vitamin D". These are three separate compounds with very different roles in the body. They should aways be referred to specifically. This conflating of the three compounds as "vitamin D", and the well known hormonal role of calcitriol leads to the mistaken belief that "vitamin D is a hormone".
The lack of understanding of 25-hydroxyvitamin D to calcitriol intracrine and paracrine signaling leads many people to assume that the immune system works better with a higher level of circulating calcitriol. This is not the case - and it wouldn't make sense, since the kidneys set this level to whatever is necessary to maintain circulating calcium ions with a very narrow range of levels, just below saturation.
A related mistake is to state that "vitamin D regulates the immune system", or "vitamin D is an immunomodulator". This combines the conflation mistake with the lack of understanding of the intracrine and paracrine signaling systems. The immune system regulates itself, by the behaviors and inter-cell signaling systems (cytokines and the above-mentioned paracrine signaling) of the individual cells - but these can only work properly if many types of immune cell are supplied with enough 25-hydroxyvitamin D.
Stating that "vitamin D is a hormone" while suggesting that people supplement thousands of IUs of it every day raises alarm in many people since this sounds like mega-dosing on hormones. However, this is not what is happening.
There is very little vitamin D3, or the less effective vitamin D2, in foods, including vitamin D2/3 fortified foods. In the absence of substantial ultraviolet B exposure of ideally white skin, all year round, and in the absence of supplemental vitamin D3 (or D2 . . .), such foods would make a small but crucial contribution to the very low level of circulating 25-hydroxyvitamin D, such as keeping it above 15 ng/mL or so (very approximately). This would greatly reduce the risk of rickets, but vitamin D fortified food, or the natural sources (some oily fish) can only supply a fraction of the vitamin D3 we need to be healthy - to attain at least 50 ng/mL circulating 25-hydroxyvitamin D.
If there was no supplemental vitamin D3, we would be reliant on getting a very small amount of it via foods and then using ultraviolet B light on the skin to make the rest.
Ultraviolet light ca. 293 nanometre wavelength gives electrons sufficient energy to break a carbon-carbon bond in one of the linked carbon rings in 7-dehydrocholesterol, which naturally occurs in the skin, since it is the last step before cholesterol in one of the two pathways by which the body synthesises the cholesterol it needs. This broken bond enables the molecule to change shape and become vitamin D3 cholecalciferol.
This is the natural way our ancestors made most of their vitamin D3. The trouble is that the exact same wavelengths which do this also break bonds in DNA and so kill cells and predispose some cells which survive to become cancerous, perhaps years later.
There is no way of generating vitamin D3 in our skin, by the action of UV-B light, without this DNA and cellular damage and so raising the risk of cancer.
If there was no supplemental vitamin D3, we could optimise our health, including lowering the general risk of cancer, by some level of UV-B skin exposure (those with brown or black skin need more, or a lot more) which would get us some of the way to 50 ng/mL circulating 25-hydroxyvitamin D, while limiting the damage caused by the UV-B. We would also wear strong eye protection, since UV-B is very damaging to the eyes.
Fortunately, vitamin D3 supplementation is inexpensive and readily available. It is fine to take a larger amount every 7 to 10 days, such as a 1.25 milligram (50,000 IU) capsule every 10 days. It takes a few months to raise the level of circulating 25-hydroxyvitamin D, so it is not necessary to supplement vitamin D3 every day.
"5000 International Units" sounds like a lot, but it is 1/8000th of a gram a day - a gram every 22 years. I am not sure what the wholesale cost of this is now, but ca. 2020, pharma grade vitamin D3 was selling, from the handful of plants worldwide which make it by UV-B irradiating 7-dehydrocholesterol made from wool fat, for USD$2.50 a gram.
The book covers these issues and much, much more in an easy to understand and entertaining manner. Every person should find useful information about sunlight, vitD and their specific health concerns succinctly presented in the book. Bill Supple aka Ben Fen from Cancer is a Parasite.
No need to write a novel or even to cite ng/ml that lay people do not comprehend.
A dog doth chase its tail. If one lives in a temperate clime, supplementation is super easy and cheap. More and more about less and less is most definitely not the way forward.
The healthiest people i know work outside. They are usually the happiest too.
With so many vitamin D supplements how does one choose the best?
15,000 peer-reviewed Vitamin D studies are at VitaminDWiki.com
Sunlight is great, but people rarely get enough.
You can get the same amount of vitamin D from 1 cent of a supplement as from lying down for 1 hour in the sun with minimal clothing if you're < 50 years old.
Example page: https://vitamindwiki.com/pages/top-10-chronic-health-problems-of-children-women-pregnancies-seniors-and-darker--ht-by-vitamin-d/
Those of us who choose to live near the equator make plenty.
It is still advisable to occasionally take more.
No need for "studies" Have digested over 30 thousand of them...